Synthesis of hydrochlorthiazide

Hydrochlorthiazide is diuretic belongs to thiazide diuretics class which reduces the reabsorbtion of electrolytes in the renal tubule, t...

Hydrochlorthiazide is diuretic belongs to thiazide diuretics class which reduces the reabsorbtion of electrolytes in the renal tubule, this causes increased excretion of water and electrolytes, including

• sodium, 
• potassium, 
• chloride, and
• magnesium

Synthesis of Hydrochlorthiaizide

Reaction Summary

3-chloroaniline is reacted with chlorosulfonic acid to yield 4-amino-6-chlorobenzene-1,3-disulfonyldichlordie molecule which on subsequent amination yields 4-amino-6-chlorobenzene-1,3-disulfonamide, upon further treatment with formaldehyde it yields HydroChlorothiazide. 

Brief Pharmacology

Hydrochlorothiazide inhibits water reabsorption in the nephron (distal convoluted tubule) by inhibiting the sodium-chloride symporter

Used in treating high blood pressure and
management of edema.