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Synthesis of Chlorothiazide

Chlorothiazide classifiedd as an antihypertensive drug that belongs to the class thiazide diuretic. Formerly known as benzothiadiazide...


Chlorothiazide classifiedd as an antihypertensive drug that belongs to the class thiazide diuretic. Formerly known as benzothiadiazide. It belongs to NaCl co-transport inhibitor on the basis of mechanism of action and also classified in Diuretic Thiazide.


Synthesis




Reaction Summary

3-chloroaniline is reacted with chlorosulfonic acid to yield 4-amino-6-chlorobenzene-1,3-disulfonyldichlordie molecule which on subsequent amination yields 4-amino-6-chlorobenzene-1,3-disulfonamide, upon further treatment with formic acid it yields Chlorothiazide.



Brief Pharmacology

Chlorothiazide acts on Distal Convulated tubules, where they interefer with reabsorbtion of Sodium therby inhibiting Chloride rebasorbtion as well.

It is indicated as adjunctive therapy in

  • edema associated with congestive heart failure, 
  • hepatic cirrhosis, and 
  • corticosteroid and estrogen therapy. 
  • It is also indicated in the management of hypertension