Medicinal chemistry of Atropine and its synthesis involves 2 major steps Synthesis of Atropine Atropine and its synthesis involv...
Medicinal chemistry of Atropine and its synthesis involves 2 major steps
Synthesis of Atropine
Atropine and its synthesis involves 2 major steps1. Synthesis of Tropine
2. Synthesis of Tropic Acid
and last step is there combination to form ultimately Atropine
The first step is Synthesis of Tropine
The immediate compound are Succinaldehyde, methylamine and Acetone to form Tropinone, this Tropinone upon reduction yields Tropine.
The second step is synthesis of Tropic Acid is carried out via Phenyl Acetic Acid and Propyl magnesium Chloride in the presence of ether and intermediate product formation, followed by subsequent treatment with H2SO4 yields tropic acid
the last step in this synthesis is combination of both products i.e Tropine + Tropic Acid to yield Atropine
Brief Pharmacology of Atropine
- Atropine action usually increase heart rate, decrease motility and peristalsis, decrease salivary secretions
- Atropine uses pre-operating medicine to decrease saliva secretions antispasmodic drug to treat peptic ulcers increase heart rate with bradycardia
- Atropine side effects tachycardia, palpatations, nasal congestion, flushing, photophobia, blurred vision, dry mouth and skin, abdominal distention, urinary retention, impotence
- Atropine is contraindicated for glaucoma