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Synthesis of Dichlorphenamide (Diclofenamide)

Reaction Summary The starting reaction takes place between 2-chlophenol and chlorosulphonic acid that yields  5-chloro-4-hydroxy...




Reaction Summary
The starting reaction takes place between 2-chlophenol and chlorosulphonic acid that yields 5-chloro-4-hydroxybenzene-1,3-disulfonyl dichloride, upon Aminolysis of last product will yield 4,5-dichlorobenzene-1,3-disulfonamide or Dichlorphenamide (Diclofenamide)

Brief Pharmacology

  • Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor.
  • Dichlorphenamide is used to treat glaucoma. By inhibiting the actions of carbonic anhydrase