Medicinal chemistry of Methohexital sodium.

Introduction : Methohexital Sodium belongs to the group of Anesthetics particularly General Anesthetics as Intravenous Anesthetics.. Desc...

Introduction:
Methohexital Sodium belongs to the group of Anesthetics particularly General Anesthetics as Intravenous Anesthetics..

Description
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia. [PubChem]

Categories

• Barbiturates
• Anesthetics
• Anesthetics, Intravenous

Analysis

sodium 5-allyl-5-(hex-3-yn-2-yl)-1-methyl-4,6-dioxohexahydropyrimidin-2-olate
Chemical Formula: C14H19N2NaO3
Exact Mass: 286.13
Molecular Weight: 286.30
m/z: 286.13 (100.0%), 287.13 (16.0%), 288.14 (1.1%)
Elemental Analysis: C, 58.73; H, 6.69; N, 9.78; Na, 8.03; O, 16.76

Pharmacology of  Methohexital Sodium

Indication	Methohexital is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation.
Pharmacodynamics	Methohexital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
Mechanism of action	Methohexital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Structure and Synthesis of  Methohexital Sodium