Page Nav

HIDE
HIDE

Gradient Skin

Gradient_Skin

Recently Published

latest

Medicinal Chemistry of SalicylAmide and its Synthesis

  Synthesis of SalicylAmide Salicylic acid ==> Salicyl chloride Salicyl chloride ==> SalicylAmide Structure Activity...

 

Synthesis of SalicylAmide

Salicylic acid ==> Salicyl chloride
Salicyl chloride ==> SalicylAmide


Structure Activity Relationship of SalicylAmide 

> Ortho position of hydoxyl (-OH) group is essential for activity
> Removing -OH group decreases its activity
> Substituion of -OH group with other substituents will affect its toxicity and activity
> Acetylation of -OH group will form 2-carbamoylphenyl acetate
> shifting of -OH group to meta or para, the activity will decrease
> substitution of - COOH group with Amide causes decrease or diminish its anti-inflammatory action

Uses

> Antipyretic
>Analgesic

Adrs


> Sedation at high doses
> may cause anemia
> Gastric intolerance


No comments