Medicinal Chemistry of SalicylAmide and its Synthesis

  Synthesis of SalicylAmide Salicylic acid ==> Salicyl chloride Salicyl chloride ==> SalicylAmide Structure Activity...

 

Synthesis of SalicylAmide

Salicylic acid ==> Salicyl chloride

Salicyl chloride ==> SalicylAmide

Structure Activity Relationship of SalicylAmide 

> Ortho position of hydoxyl (-OH) group is essential for activity

> Removing -OH group decreases its activity

> Substituion of -OH group with other substituents will affect its toxicity and activity

> Acetylation of -OH group will form 2-carbamoylphenyl acetate

> shifting of -OH group to meta or para, the activity will decrease

> substitution of - COOH group with Amide causes decrease or diminish its anti-inflammatory action

Uses

> Antipyretic

>Analgesic

Adrs

> Sedation at high doses

> may cause anemia

> Gastric intolerance