Medicinal Chemistry of Sulfamerazine

Sulfamerazine belongs to antibacterial drugs (bacteriostatic) that contains Sulfonamide as parent structure. it is used as bronchi...

Sulfamerazine belongs to antibacterial drugs (bacteriostatic) that contains Sulfonamide as parent structure.
it is used as

1. bronchitis, 
2. prostatitis and 
3. Urinary tract infections

Sulfamerazine as it is belong to Sulfonamide shows following mechanism

It inhibits bacetrial folic acid synthesis by competing PABA with dihydrofolate synthetase

Competitive inhibitor of  dihydrofolate synthetase, this enzyme is used in folate synthesis in bacteria, hence Sulfamerzine interfere with this pathway

 and ultimately decresing the synthesis of bacterial nucleotides and DNA

Synthesis of Sulfamerazine

Synthesis of Sulfamerazine Step 01
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Synthesis of Sulfamerazine Step 02
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Synthesis of Sulfamerazine Step 03
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