Medicinal chemistry of Methoxyflurane

Introduction : Methoxyflurane belongs to the group of Anesthetics particularly General Anesthetics. Description It is one of the most po...

Introduction:
Methoxyflurane belongs to the group of Anesthetics particularly General Anesthetics.

Description
It is one of the most potent anaesthetic agents frequently used in practice today. In fact, it is employed to cause comparatively light anaesthesia with deep analgesic and muscle relaxation, features which make it convenient for short surgical operations, e.g., obstetrics.
Analysis

2,2-dichloro-1,1-difluoro-1-methoxyethane
Chemical Formula: C3H4Cl2F2O
Exact Mass: 163.96
Molecular Weight: 164.97
m/z: 163.96 (100.0%), 165.96 (64.1%), 167.95 (10.2%), 164.96 (3.3%), 166.96 (2.1%)
Elemental Analysis: C, 21.84; H, 2.44; Cl, 42.98; F, 23.03; O, 9.70

Pharmacology of Methoxyflurane

ndication	For use in the induction and maintenance of general anesthesia
Pharmacodynamics	Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Mechanism of action	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.